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Primary Biliary Cirrhosis, now known as Primary Biliary Cholangitis (PBC), is an autoimmune disease of the liver in which the body attacks its own healthy cells. It causes gradual, progressive destruction of the small bile ducts of the liver; this leads to the buildup of bile and other toxins. The accumulation of bile and toxins results in a condition known as Cholestasis.
The exact cause for Primary Biliary Cholangitis is unknown. However, researchers believe that it occurs when the body attacks its own cells. Primarily, the T-lymphocytes, a type of white blood cells, attack the liver’s healthy cells leading to significant damage.
The inflammation associated with cell damage spreads to other liver cells, gradually impairing liver functions. The damaged cells are replaced by scar tissue (fibrosis), which leads to cirrhosis. Scarring of the liver tissue, Cirrhosis, makes it difficult for the liver to work properly.
The following are the risk factors:
The following are the symptoms:
The diagnosis is made when a doctor examines the patient physically, checks relevant symptoms, and performs certain lab tests, such as cholesterol tests, liver function tests, and antibody test for signs of autoimmune disorders.
Following is the management:
Please consult your doctor for further information.
Early diagnosis can lead to effective and successful treatment. If your symptoms do not improve within a few days, or you experience any of the symptoms mentioned above, such as upper abdomen pain, itching, and discomfort, please see a doctor.
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